I believe Panama City is underrated as a tourist destination! Tocumen airport is probably one of the best in the whole Latin America with many direct connections to Europe, North and South America. If arriving from Europe is it worth spending four days in Panama City and continue to Cartagena or Quito in South America?
If so there should one stay in Panama City? Ancon hill there American staff lived during the time the Panama Canal was run by Americans? In old well maintained Casco Viejo with the 1600 century old houses? Stay in centrally located El Cangrejo with wonderful restaurants and affordable hotels? Calzada de Amador the causeway with great restaurants and easy access to Panama Canal? Punta Paitilla the smartest parts of the city there most of the American lives in Panama City?